Many of the 3D settings in NVCP just don’t work universally enough or have a tangible enough impact to recommend. ‘Optimal power’ is a good balance between performance and power. It’s overkill, and bad for the longevity of your card.
You may also be tempted to crank ‘Power management mode’ up to ‘maximum performance’, but this will make your GPU run loud and hot at its max clock speeds when gaming.